![]() The baseline demographics of the remaining 59 and 60 participants in arm A and arm B, respectively, are summarized in Table 1. Thus, the allocation was concealed for participants and all trial personnel.įrom May, 2021, to September, 2021, a total of 121 participants enrolled in the study and were randomly assigned to either arm A or arm B ( Fig. 1B) however, two participants assigned to arm B dropped out of the study prior to the first dosing period. The packs of study medicine were labelled with study-ID and dosing period. The placebo capsules were specifically created to resemble capsules of CoQ10 and were undistinguishable. Upon inclusion, participants were granted study-ID chronologically and received appertaining prepared study medicine. Allocation lists were obtained by the pharmaceutical supplier for preparation of the study medicine without the involvement of trial personnel. No pre-randomizing stratification occurred. The allocation list was stored in an electronic database with a concealed de-identification code, in case premature blinding was needed. ![]() Proper concealment of randomization was obtained by the use of an external randomization service (Clinical Trial Unit, Department of Clinical Medicine, Aarhus University, Denmark), who created the computer-generated sequence. Allocation lists were generated at a 1:1 ratio using permuted blocks with random varying sizes of four and eight. In addition, we excluded patients who presented with symptoms associated with acute COVID-19, hypersensitivity to any components in the study drugs, reduced liver and/or kidney function, or current pregnancy.Įligible patients were randomized to either arm A or arm B ( Fig. 1). The following inclusion criteria were applied: >18 years of age ability to give written informed consent a history of SARS-CoV-2 infection based on either a PCR test or antibody test and PCC-related symptoms that were diagnosed by a specialized infectious disease physician at the PCC Outpatient Clinic and are not attributable to any other comorbidity or condition. In Denmark, patients are eligible for referral to a specialized PCC Outpatient Clinic if they have more than two persisting symptoms 12 weeks after COVID-19. Participants were recruited from the PCC Outpatient Clinic at Aarhus University Hospital and Gødstrup Hospital, Denmark, directly or by letter invitation. The trial was conducted at the Department of Infectious Diseases at Aarhus University Hospital, Denmark. This study was an investigator-initiated, randomized, double-blind, placebo-controlled interventional clinical trial with a crossover design. The Lancet Regional Health – Western Pacific.The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology.Some skills cost more points than others, you don't have to spend points everytime you're given the chance.It is highly suggested you do so when a certain skill is needed but hasn't yet been obtained. Skills can be reset on demand, whenever the player chooses.Gives the Thief a new weapon entirely that deals additional damage, sets flammable things on fire, and breaks some objects.Īdds damage and area of effect to fire arrow. A fully drawn bow gains the frost arrow upgrade. Wears off twice as fast when moving, and touching monsters or attacking removes stealth.Īllows the Thief to fire two arrows at the same time. Lesser enemies are frozen solid by two hits.Īllows the Thief to stay concealed from enemies for 10 seconds. Needs to be charged by holding down the attack or throw button.Īllows the Thief to chilll and slow enemies with fully drawn arrows. Charging Knight can also jump longer distances.Īdds area damage to the Storm Hammer. ![]() The Knight can rampage through enemies and injure them. Deals more damage and can set flammable things on fire. The hammer can even break some stone objects.Īdds a fire effect to the Sword. The amount of skill points that each skill costs is shown beside that skill in parentheses.Īllows the Wizard to can grab and levitate monsters.Īllows the Wizard to conjure up to two items to exist at the same time.Īllows the Wizard to conjure up to three items to exist at the same time.Īllows the Wizard to conjure up to four items to exist at the same time.įrost Shield slows down and freezes melee enemies that hit the Knight. If the player so chooses to place skill points in any of the three characters' skill trees, the following can be obtained in order from left to right in the picture shown above. The picture shown above displays these individual Skill Trees for each class.
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